Resources

Signals

• Association of serum creatinine-to-albumin ratio with hyperandrogenemia and low sex hormone-binding globulin in women of reproductive age: a cross-sectional analysis of NHANES 2013-2016. ↗

  Qianying Yang · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · PubMed · 1 Dec 2026 · US

  This cross-sectional US NHANES analysis examined associations between the creatinine-to-albumin ratio and hormonal features relevant to PCOS. Associations with low sex hormone-binding globulin and free-androgen-index-defined hyperandrogenemia weakened after metabolic adjustment, and the design cannot establish causality.

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• Beyond reproduction: the emerging role of FSH in postmenopausal aging. ↗

  María S Vallejo, Alejandro Paradas, Hernán Neira · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · PubMed · 1 Dec 2026 · GLOBAL

  This review examines possible roles of follicle-stimulating hormone in bone, metabolic, cardiovascular and brain changes after menopause. It distinguishes associations from causality and notes experimental benefits of reducing FSH alongside inconclusive preliminary clinical evidence on cognition.

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• Ultrasound-Guided Radiofrequency Ablation for Focal Adenomyosis ↗

  University Hospital Pilsen · ClinicalTrials.gov · 30 Oct 2026 · EU

  This Czech study will evaluate ultrasound-guided radiofrequency ablation for symptomatic focal adenomyosis in women wishing to preserve the uterus. It is not yet recruiting and will assess safety, pain severity and menstrual blood loss.

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• Cardiovascular Disease Risk in Women With Endometriosis ↗

  Yale University · ClinicalTrials.gov · 16 Oct 2026 · US

  This completed US study investigated estrogen suppression and endothelial dysfunction in women with endometriosis. Its stated focus is cardiovascular disease risk in this population.

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• Association of Ultrasound Features of the Myometrium Suggestive of Adenomyosis and Clinical Symptoms ↗

  Swiss GO Trial Group · ClinicalTrials.gov · 16 Oct 2026 · EU

  This recruiting study in Belgium, Poland, Spain and Switzerland examines relationships between ultrasound features suggestive of adenomyosis and clinical symptoms. It aims to establish a disease-severity reporting system using a single ultrasound visit and symptom questionnaires without intervention.

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• Prospective trial of [18F]AlF-FAPI-74 for PET imaging of fibroblast activation protein in patients with endometriosis ↗

  UZ Leuven · EU CTIS · 7 Oct 2026 · EU

  This prospective Belgian trial investigates [18F]AlF-FAPI-74 PET imaging of fibroblast activation protein in patients with endometriosis. The metadata provide no findings or interpretation of the numeric study status.

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• A Phase 2, randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of 2 doses of vipoglanstat in patients with moderate to severe endometriosis-related pain – the NOVA trial ↗

  Gesynta Pharma AB · EU CTIS · 6 Oct 2026 · EU

  The phase 2 NOVA trial evaluates the efficacy and safety of two doses of vipoglanstat against placebo for moderate to severe endometriosis-related pain. This randomized, double-blind trial lists sites in Italy, Hungary, Poland, Czechia, Bulgaria, and Romania.

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• A Lifelong Focus on Women’s Health ↗

  Yevgeniya Nusinovich, Sacha Vignieri, Sarah Ross et al. · Science · Crossref · 1 Oct 2026 · GLOBAL

  Science lists a collection or special issue titled “A Lifelong Focus on Women’s Health.” The supplied metadata does not identify specific conditions or a geographic focus.

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• Endometriosis and Early-Onset Cardiovascular Disease Across Levels of Systemic Inflammation: A Cross-Sectional Study of NHANES 1999–2006 ↗

  Oli C, Chichetto N. · medRxiv · medRxiv · 30 Sept 2026 · US

  Not peer reviewed

  This cross-sectional US preprint found that self-reported endometriosis was associated with higher odds of early-onset cardiovascular disease. Associations varied across inflammation strata, but formal interaction tests were not significant and the findings require prospective investigation.

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• COMPASS - COpenhagen MenoPAuSe Study ↗

  Region Hovedstaden · EU CTIS · 9 Jul 2026 · EU

  COMPASS is the Copenhagen Menopause Study, with menopause listed as its condition. The trial lists Denmark as its country, but the supplied metadata does not describe an intervention.

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• Randomized, Double-blind, Placebo-controlled, Proof-of-concept Phase II Trial Investigating the Effect of Valproic Acid in Women with Adenomyosis. ↗

  CCDRD Cooperative Clinical Drug Research and Development AG, Nadezhda Reproductive Science OOD · EU CTIS · 4 Mar 2026 · EU

  This randomized, double-blind, placebo-controlled phase II trial investigates valproic acid in women with adenomyosis. The trial lists Bulgaria as its country.

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• Optimizing metformin use in polycystic ovary syndrome - A randomized controlled trial ↗

  HUS-yhtymae · EU CTIS · 2 Sept 2025 · EU

  This randomized controlled trial investigates optimizing metformin use in polycystic ovary syndrome. It lists Finland as its country.

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• Towards a treatment for accelerated maturation in girls testing spiomet in a randomised placebo controlled, multicentre study. ↗

  Hospital Universitari De Girona Doctor Josep Trueta · EU CTIS · — · SPAIN

  This randomized, placebo-controlled multicentre study tests SPIOMET as a treatment for accelerated maturation in girls. It lists Spain and identifies advanced puberty, accelerated bone maturation and PCOS in its condition metadata.

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• The effect of transdermal 17-β-estradiol/progesterone supplementation on glucose regulation in peri- and postmenopausal women with type 1 and type 2 diabetes ↗

  Amsterdam UMC Stichting · EU CTIS · — · EU

  This trial examines transdermal estradiol/progesterone supplementation and glucose regulation in peri- and postmenopausal women with type 1 and type 2 diabetes. It lists the Netherlands as its country.

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• Personalized Treatment for Endometriosis: A Study on the Safety and Kinetics of Dienogest in Women with Different Gene Variants ↗

  Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Princesa · EU CTIS · — · SPAIN

  This Spanish study examines dienogest safety and kinetics in women with different gene variants, with a stated aim of personalized endometriosis treatment. The condition field lists healthy volunteers rather than patients with endometriosis.

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• Use of a new diagnostic tool in the detection and characterization of endometriosis lesions. ENDO-TEP ↗

  Centre Hospitalier Universitaire De Toulouse · EU CTIS · — · EU

  The ENDO-TEP study in France investigates a new diagnostic tool for detecting and characterizing endometriosis lesions. The supplied metadata do not specify the tool or report findings.

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• CARESS Study: Cabergoline for the Reduction of Endometriosis Symptoms and Lesion Size ↗

  Hospital Clinico San Carlos · EU CTIS · — · SPAIN

  The CARESS study in Spain investigates cabergoline for reducing endometriosis symptoms and lesion size. The supplied metadata contain no results or detailed study design.

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• Acupuncture or Metformin for Insulin Resistance in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial ↗

  Karolinska Institutet · EU CTIS · — · EU

  This randomized controlled trial examines acupuncture or metformin for insulin resistance in women with PCOS. It lists Sweden as its country.

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• A Phase II, randomised, multi-centric, multi-national clinical trial to evaluate the efficacy, tolerability, and safety of a fixed dose combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) for adolescent girls and young adult women (AYAs) with polycystic ovary syndrome (PCOS). ↗

  Fundacio Sant Joan De Deu · EU CTIS · — · EU

  This multinational randomized phase II trial evaluates the efficacy, tolerability and safety of SPIOMET, a fixed-dose combination of spironolactone, pioglitazone and metformin, in adolescent girls and young adult women with PCOS. It lists Austria, Spain, Denmark, Norway and Italy.

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• A Clinical Trial of Tirzepatide (LY3298176) in Subjects With Overweight or Obesity and PCOS-related Ovarian Dysfunction (PERIODS) ↗

  Rheinische Friedrich-Wilhelms-Universitaet Bonn · EU CTIS · — · EU

  PERIODS investigates tirzepatide in people with overweight or obesity and PCOS-related ovarian dysfunction. The trial lists Germany as its country.

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